New approach to bicyclo[5.3.0]decanes: stereoselective guaiane synthesis.
نویسندگان
چکیده
[reaction: see text] A conceptually new and highly versatile approach to bicyclo[5.3.0]decanes, based on dichloroketene cycloaddition-diazoalkane ring expansion, is disclosed, and its relevance to natural product synthesis is demonstrated through the preparation of three guaiane sesquiterpenes. A concise total synthesis of a guaian-8,12-olide, 6-deoxygeigerin, highlights the effectiveness of the new methodology.
منابع مشابه
A unified approach to the daucane and sphenolobane bicyclo[5.3.0]decane core: enantioselective total syntheses of daucene, daucenal, epoxydaucenal B, and 14-para-anisoyloxydauc-4,8-diene.
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ورودعنوان ژورنال:
- Organic letters
دوره 5 23 شماره
صفحات -
تاریخ انتشار 2003